In recent study, The Queen Elizabeth Hospital Human Research Ethics Committee, Adelaide, Australia (reference number HREC/15/TQEH/132) approvedthe collection of nasal mucus. Mucus samples from patients with CRS were collected from patients having endoscopic sinus surgery at the Departmentof Otorhinolaryngology Head and Neck Surgery of The Queen Elizabeth Hospital, Adelaide, Australia. Patient consent and mucus samples were obtained before surgery. Mucus samples from healthy patients were collected from patients who were undergoing endoscopic skull base surgery or septoplasty and had no clinical or radiologic evidence of sinus disease. Patient comorbidities and disease severity were documented preoperatively. Nasal mucosa tissue was obtained intraoperatively and reviewed by a pathologist. Patients who were younger than 18 yearsof age, pregnant, and undergoing systemic immu nosuppression were excluded.
A total of 33 patients were included in this study. The nasal mucosal lamina propria of the patients with Nasal Polyps showed increased eosinophiland lymphoplasmacytic infiltration, respectively. The eosinophilinfiltration was diffusely distributed with occasional extensioninto the respiratory epithelium, whereas the infiltration of lymphocytes and plasma cells was either diffuse or perivascular .
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